Which brings us to mandatory vaccination. Sure, it's a public health issue. Unvaccinated people may pose a greater risk to the general population. On the other hand, can government literally inject pathogens, dead or alive (attenuated), directly into our bodies, with the intention of modifying our immune systems without our consent? That is just about as invasive as you can get.
Having handily survived chickenpox, mumps and both kinds of measles as a child, I can tell you that a full infection of those diseases is quite survivable, and could provide better lifelong immunity. Though there is risk, it is certainly nothing like pertussis, smallpox and polio, for which I was immunized.
I think it is probably best to be immunized against certain killers. It may be better to be immunized against the less severe diseases as well. I can accept the idea of mandatory immunization in order to be admitted into various public and private institutions, such as schools, as long as conscientious objectors still have alternatives (such as home schooling).
This is not anti-science: I have been a lifelong student of science, and I know perhaps better than most, that although modern science and technology is nothing short of miraculous in many respects, science still doesn't have everything figured out. Biological systems, including our immune systems, are not well understood. Vaccines are not without risk. We don't have long term data for the newer vaccines. By definition, that won't happen until the vaccines have existed for one average human lifetime. Our immune systems are unpredictable, and can be triggered to react violently and badly. Autoimmune diseases are difficult to treat. It is not irrational to not want to risk it. But it is tyrannical to mandate the exchange of one risk for another. We should have a choice.